The top red spot is for SPI usage or for I2C usage. So if you are going to use I2C then you need to solder what you see in the picture.
The bottom red spot is to activate the pull-up resisters that are on the breakout board. If you are using pull-up resisters from another source then leave the red spot open.
Regarding the pull up resistors: I am using the breakout board on a Jeenode v6 jeelabs.net/projects/hardware/wiki/JeeNode.The Board is directly connected to a port - I do not see anythig mentioned with pull up resistors on the jeenode so I guess I need to activate?